Let URnU\subseteq\mathbb R^n be and f:URf:U\to\mathbb R be of . Then for every aUa\in U and all indices i,ji,j,

2fxixj(a)=2fxjxi(a).\frac{\partial^2 f}{\partial x_i\partial x_j}(a)=\frac{\partial^2 f}{\partial x_j\partial x_i}(a).
Remarks

Apply at each aUa\in U. The C2C^2 hypothesis guarantees that the mixed exist and are near aa.