A homotopy nn-sphere is a that is to the standard SnS^n. A smooth homotopy sphere is a closed with the same homotopy type.

Every manifold homeomorphic to SnS^n is a homotopy sphere, but the converse is the content of the generalized Poincaré problem. A smooth homotopy sphere can be topologically standard while carrying an exotic smooth structure, meaning it is not to the standard smooth sphere.