Consider the short exact sequences of abelian groups
0→2Z→Z→Z/2Z→0
and
0→4Z→2Z→Z/2Z→0,
where the quotient map 2Z→Z/2Z is the identification 2Z/4Z≅Z/2Z.
Define a morphism of short exact sequences by:
left vertical map 2Z→4Z, x↦2x (an isomorphism),
middle vertical map Z→2Z, x↦2x,
right vertical map Z/2Z→Z/2Z, identity.
The ends are isomorphisms, so the short five lemma implies Z⋅22Z is an isomorphism.
Example 2: Linear algebra version
Let k be a field and let U⊂V and U′⊂W be subspaces. Given a commutative diagram of short exact sequences
0→U→V→V/U→0⟶0→U′→W→W/U′→0
where the induced maps U→U′ and V/U→W/U′ are isomorphisms, the short five lemma forces V→W to be an isomorphism.
Example 3: “If a map is an isomorphism on submodule and quotient, it is an isomorphism”
Let f:M→N be a module map, and suppose there are submodules K⊆M, L⊆N such that f(K)⊆L, and f induces isomorphisms K∼L and M/K∼N/L. Applying the short five lemma to